| Primary Identifier | IPR040535 | Type | Domain |
| Short Name | NLRC4_HD |
| description | This is a helical domain found in NLRC4, an nucleotide-binding and oligomerization domain-like receptor (NLR) protein. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important α-helix of the NBD (nucleotide binding domain) in NLRC4. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions []. Other proteins carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1), also known as neuronal apoptosis inhibitory protein (Naip). |
