| Primary Identifier | IPR035752 | Type | Domain |
| Short Name | SPRY/PRY_TRIM1 |
| description | This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM1 (also known as MID2 or midline 2). MID2 and its close homologue, TRIM18 (also known as MID1), both contain a B30.2-like domain at their C terminus and a single fibronectin type III (FN3) motif between it and their N-terminal RBCC domain. Mid1 and Mid2 are ubiquitin ligases that regulate microtubule dynamics and whose mutation is associated with X-linked developmental disorders. Mid2 regulates cell division through the ubiquitination of astrin on K409, which is critical for its degradation and proper cytokinesis []. |
