| Primary Identifier | IPR040889 | Type | Domain |
| Short Name | RFX5_N |
| description | This entry represents the N-terminal domain of regulatory factor X (RFX)-5, which is part of the human RFX complex. The RFX complex (consists of RFX5, RFXAP and RFXB) is involved in the regulation of the expression of the major histocompatibility complex class II (MHCII) gene products essential for the initiation and regulation of the mammalian immune response. The N-terminal domain of RFX5 is responsible for homodimerization of RFX5 which promotes folding of the C-terminal domain of RFXAP. The folding of RFXAP results in the formation of a potential binding site for RFXB to bind to the MHCII promoter []. |
