| Primary Identifier | IPR037227 | Type | Homologous_superfamily |
| Short Name | EndoU-like |
| description | This entry represents the EndoU-like endoribonucleases from a variety of organisms that range from viruses to humans. The founding member XendoU is a uridylate-specific, divalent cation-dependent enzyme that produces molecules with 2',3'-cyclic phosphate ends [, ]. The human EndoU, known as PP11, is a endoribonuclease with placental tissue specificity [].In human SARS coronavirus, EndoU (also known as NSP15) is part of the replicase-transcriptase complex that plays important roles in virus replication and transcription. NSP15 is a Uridylate-specific endoribonuclease that cleaves the 5'-polyuridines from negative-sense viral RNA, termed PUN RNA [], either upstream or downstream of uridylates, at GUU or GU to produce molecules with 2',3'-cyclic phosphate ends []. PUN RNA is a CoV MDA5-dependent pathogen-associated molecular pattern (PAMP) []. |
