| Primary Identifier | IPR037298 | Type | Domain |
| Short Name | PheC_PBP2 |
| description | This entry represents the periplasmic binding protein type 2 (PBP2) domain found in cyclohexadienyl dehydratase PheC []. Proteins containing this domain catalyze the decarboxylation of prephenate to phenylpyruvate in the alternative phenylalanine biosynthesis pathway in some proteobacteria and archaea []. The PheC proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap []. Since the PheC proteins are so similar to periplasmic binding proteins, (PBP), it is evolutionary plausible that several pre-existing PBP proteins might have been recruited to perform the enzymatic function. |
