| Primary Identifier | IPR015714 | Type | Family |
| Short Name | Lymphocyte_func-assoc_Ag_3 |
| description | The LFA-3 (CD2) adhesion molecule is a cell surface protein expressed by T cells and natural killer cells. LFA-3's extracellular region contains immunoglobulin-like domains that are glycosylated at two sites and can mediate homodimerisation []. Ligation of LFA3 by CD58 in humans or CD48 in mice helps T cells adhere to antigen-presenting cells, and initiates signal transduction pathways that enhance signalling through the T cell receptor for antigen. LFA-3 knockout mice exhibit essentially normal immune function [], and it is thought that LFA-3 is somewhat functionally redundant with other T cell co-stimulatory receptors such as CD28 []. |
