| Primary Identifier | IPR039746 | Type | Family |
| Short Name | FOG |
| description | This entry represents the FOG (Friend of GATA) family, whose members are zinc finger cofactors that regulate GATA factor-activated gene transcription. There are two FOG proteins in mammals, FOG1 and FOG2. They are essential cofactors that act via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3 []. In mice, FOG1 is expressed predominantly within the hematopoietic system, while FOG2 is expressed outside of blood, mostly in heart, brain, gonads, and liver [].This entry also includes the FOG homologue from fruit flies, U-shaped (Ush), which is expressed in circulating and lymph gland hemocytes, where it plays a critical role in controlling blood cell proliferation and differentiation []. |
