| Primary Identifier | IPR039780 | Type | Family |
| Short Name | Mot2 |
| description | NOT4, also known as CNOT4 or MOT2, is a component of the CCR4-NOT complex, a global negative regulator of RNA polymerase II transcription []. It associates with polysomes and contributes to the negative regulation of protein synthesis [, , , , , , , ]. NOT4 functions as an E3 ubiquitin-protein ligase that interacts with a specific E2, Ubc4/5 in yeast, and the orthologue UbcH5B in humans, and ubiquitinates a wide range of substrates, including ribosome-associated factors []. Thus, it plays a role in cotranslational quality control (QC) through ribosome-associated ubiquitination and degradation of aberrant peptides. NOT4 contains a C4C4-type RING finger motif, whose overall folding is similar to that of the C3HC4-type RING-HC finger, a central RNA recognition motif (RRM), and a C-terminal domain predicted to be unstructured []. |
