| Primary Identifier | IPR035586 | Type | Domain |
| Short Name | PI3K_p85beta_SH3 |
| description | This entry represents the SH3 domain of PI3K (phosphoinositide-3-kinase) subunit beta (also known as subunit p85-beta). Class I PI3Ks convert PtdIns(4,5)P2 to the critical second messenger PtdIns(3,4,5)P3. Class IA PI3Ks consist of a p110 catalytic subunit bound to one of five regulatory subunits, generated by alternative splicing of three different genes: p85alpha, p85beta, and p55gamma [, ]. The p85 subunits contain the SH3, RhoGAP, and SH2 domains. They recruit the p110 subunit to the membrane, where p110 phosphorylates inositol lipids []. Vertebrates contain two p85 isoforms, alpha and beta. In addition to regulating the p110 subunit, p85beta binds CD28 and may be involved in the activation and differentiation of antigen-stimulated T cells []. |
