| Primary Identifier | IPR035640 | Type | Domain |
| Short Name | Endophilin_B2_SH3 |
| description | Endophilin-B2 is a cytoplasmic protein that colocalizes to the cytoplasmic compartment of the cell together with Bax and is excluded from the nucleus []. It is overexpressed in prostate cancer metastasis and has been identified as a cancer antigen with potential utility in immunotherapy []. Endophilins play roles in synaptic vesicle formation, virus budding, mitochondrial morphology maintenance, receptor-mediated endocytosis inhibition and endosomal sorting. They contain an N-terminal N-BAR domain (BAR domain with an additional N-terminal amphipathic helix), followed by a variable region containing proline clusters, and a C-terminal SH3 domain. Endophilin-B2 forms homo- and heterodimers (with endophilin-B1) through its BAR domain []. This entry represents the SH3 domain of endophilin-B2. |
