| Primary Identifier | IPR035645 | Type | Domain |
| Short Name | GRAP_N_SH3 |
| description | GRAP is a GRB-2 like adaptor protein that is highly expressed in lymphoid tissues. It acts as a negative regulator of T cell receptor (TCR)-induced lymphocyte proliferation by downregulating the signaling to the Ras/ERK pathway []. It has been identified as a regulator of TGFbeta signaling in diabetic kidney tubules and may have a role in the pathogenesis of the disease []. GRAP contains an N-terminal SH3 domain, a central SH2 domain, and a C-terminal SH3 domain. |
