| Primary Identifier | IPR035677 | Type | Domain |
| Short Name | ASAP2_SH3 |
| description | This entry represents the SH3 domain of ASAP2 (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2). ASAP2 (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; also known as AMAP2 or PAG3) is a PH domain-containing ArfGAP. It mediates the functions of Arf GTPases via dual mechanisms: it exhibits GTPase activating protein (GAP) activity towards class I (Arf1) and II (Arf5) Arfs; and it binds class III Arfs (GTP-Arf6) stably without GAP activity []. It binds paxillin and is implicated in Fcgamma receptor-mediated phagocytosis in macrophages and in cell migration []. ASAP2 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, ankyrin (ANK) repeats, and a C-terminal SH3 domain.ArfGAPs are a protein family containing the ArfGAP domain. There are 31 genes encoding ArfGAPs in human []. They catalyse the hydrolysis of GTP that is bound to Arf, thereby converting Arf-GTP to Arf-GDP []. |
