| Primary Identifier | IPR035716 | Type | Domain |
| Short Name | Cortactin_SH3 |
| description | Cortactin was originally identified as a substrate of Src kinase []. It is an actin regulatory protein that binds to the Arp2/3 complex and stabilizes branched actin filaments [, ]. It is involved in cellular processes that affect cell motility, adhesion, migration, endocytosis, and invasion [, , , ]. Cortactin contains an N-terminal acidic domain, several copies of a repeat domain found in cortactin and HS1, a proline-rich region, and a C-terminal SH3 domain []. The N-terminal region interacts with the Arp2/3 complex and F-actin, and is crucial in regulating branched actin assembly []. Cortactin also serves as a scaffold and provides a bridge to the actin cytoskeleton for membrane trafficking and signaling proteins that bind to its SH3 domain. Binding partners for the SH3 domain of cortactin include dynamin2, N-WASp, MIM, FGD1, among others []. This entry represents the SH3 domain of cortactin. |
