| Primary Identifier | IPR035723 | Type | Domain |
| Short Name | PLCgamma2_SH3 |
| description | PLCgamma2 (phospholipase C-gamma-2 or 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2) is primarily expressed in haematopoietic cells, specifically in B cells []. It is activated by tyrosine phosphorylation by B cell receptor (BCR) kinases and is recruited to the plasma membrane where its substrate is located. It is required in pre-BCR signaling and in the maturation of B cells []. PLCs catalyze the hydrolysis of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2]to produce Ins(1,4,5)P3 and diacylglycerol (DAG). Ins(1,4,5)P3 initiates the calcium signaling cascade while DAG functions as an activator of PKC [, ]. PLCgamma2 contains a Pleckstrin homology (PH) domain followed by an elongation factor (EF) domain, two catalytic regions of PLC domains that flank two tandem SH2 domains, followed by an SH3 domain and C2 domain. |
