| Primary Identifier | IPR035736 | Type | Domain |
| Short Name | Stac3_SH3_1 |
| description | Stac (SH3 and cysteine-rich domain-containing) proteins are putative adaptor proteins that contain a cysteine-rich C1 domain and one or two SH3 domains at the C terminus. There are three mammalian members (Stac1, Stac2, and Stac3) of this family. Stac1 and Stac3 contain two SH3 domains while Stac2 contains a single SH3 domain at the C terminus. Stac3 is specific to skeletal muscle and is a component of the excitation-contraction coupling machinery. A mutation in the Stac3 gene has been linked to a severe muscle disease, Native American myopathy (NAM) [, ].This entry represents the first SH3 domain of Stac3. |
