| Primary Identifier | IPR035744 | Type | Domain |
| Short Name | CASS4_SH3 |
| description | CASS4, also called HEPL (HEF1-EFS-p130Cas-like), is a member of the CAS family. It localizes to focal adhesions and plays a role in regulating FAK activity, focal adhesion integrity, and cell spreading []. CAS (Crk-associated substrate) family members are adaptor proteins that contain a highly conserved N-terminal SH3 domain, an adjacent unstructured domain (substrate domain) containing multiple tyrosine phosphorylation sites that enable binding by SH2-domain containing proteins, a serine-rich four-helix bundle, and a FAT-like C-terminal domain. Most of these domains mediate protein-protein interactions. Through these interactions, they assemble larger signaling complexes that are essential for cell proliferation, survival, migration, and other processes []. The CAS family consists of four members: BCAR1, HEF1, EFS, and CASS4 []. |
