| Primary Identifier | IPR001496 | Type | Domain |
| Short Name | SOCS_box |
| description | The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family []but was later also found in:the WSB (WD-40-repeat-containing proteins with a SOCS box) family,the SSB (SPRY domain-containing proteins with a SOCS box) family,the ASB (ankyrin-repeat-containing proteins with a SOCS box) family,and ras and ras-like GTPases [].The SOCS box found in these proteins is an about 50 amino acid C-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues []. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box [], which binds to the Elongin BC complex [, ]. It has been demonstrated that this association couple bound proteins to the ubiquitination or proteasomal compartments [, ]. |
