| Primary Identifier | IPR037340 | Type | Domain |
| Short Name | SSB2_SOCS |
| description | This entry represents the SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins). SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to interact with c-Met, the hepatocyte growth factor receptor [, ]. It also regulates inducible nitric oxide synthase (iNOS) by targeting it for proteasomal degradation []. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ]. |
