| Primary Identifier | IPR037452 | Type | Domain |
| Short Name | Fer_F-BAR |
| description | Fer () is a tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis [, ]. In non-small cell lung cancer cells, Fer kinase expression has been linked to cell invasion and tumour metastasis []. It also acts downstream of EGFR (EGF receptor) to promote activation of NF-kappa-B and cell proliferation [].This entry represents the F-BAR domain of Fer. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization [, ]. |
