| Primary Identifier | IPR037571 | Type | Family |
| Short Name | MASP2 |
| description | This entry represents mannan-binding lectin-associated serine peptidase 2 (MASP2; MEROPS identifier S01.229), a serine endopeptidase from family S1 (chymotrypsin family) which is a component in the activation of complement in the lectin pathway. MASP2 has trypsin-like specificity and it processes complement components C2 and C4 []. The fragments released, C2a and C4b, form the C3/C5 convertase. The specificity of MASP2 is identical to that of complement component C1s, but from the solved tertiary structure that enzyme-substrate interactions are different []. MASP2 is inhibited by C1 inhibitor []. MASP2 forms a homodimer, stabilized by two Ca2+ions, before it binds to mannose-binding protein C []. MASP2 autoactivates itself to a two-chain form. |
