| Primary Identifier | IPR039979 | Type | Family |
| Short Name | PRPF18 |
| description | The splicing factor Prp18 is required for the second step of pre-mRNA splicing. PRP18 appears to be primarily associated with the U5 snRNP.The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known []. This fragment is fully active in yeast splicing in vitroand includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five α-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two α-helices and may interact with the U5 small nuclear ribonucleoprotein particles []. |
