| Primary Identifier | IPR037353 | Type | Family |
| Short Name | ASH2 |
| description | The trithorax-group (trxG) protein Ash2 from C. elegans (or ASH2L in mammals) is a component of the Set1/Ash2 histone methyltransferase (HMT) complex that methylates 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation [, ]. Mammals posses several SET1 family proteins (MLL1-4, SET1A, and SET1B). ASH2L is a core component of all the resulting mammalian histone H3K4 methyltransferase complexes, including mixed lineage leukemia (MLL) complexes [].S. cerevisiae Bre2 is homologous to Ash2 []. TRAUCO (TRO) is the homologue from Arabidopsis, which is required for early embryogenesis []. |
