| Primary Identifier | IPR033928 | Type | Domain |
| Short Name | EPS8_PTB |
| description | Epidermal growth factor receptor kinase substrate (EPS8) is a regulator of Rac signaling [, , ]. It consists of a phosphotyrosine-binding (PTB) and an SH3 domain.PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules []. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lack tyrosine residues altogether []. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine []. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains [].The entry refers to the PTB domain found in EPS8, part of the Dab-like subgroup. |
