| Primary Identifier | IPR011026 | Type | Homologous_superfamily |
| Short Name | WAS_C |
| description | The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Actin nucleation-promoting factor WAS protein (WASP) family members []. Mutations in WASP lead to the Wiskott-Aldrich syndrome, a paediatric disorder characterised by actin cytoskeletal defects in haematopoietic cells, leading clinically to thrombocytopenia, eczema and immunodeficiency. The WASP proteins signal to the cytoskeleton through the Arp2/3 complex, an actin-nucleating assembly that regulates the structure and dynamics of actin filament networks at the leading edge of the cell.WASP family members have unique N-terminal regions, followed by a central segment rich in proline, and a common C-terminal region. The C-terminal region contains the VCA region that binds the Arp2/3 complex and actin, while the distinct N-terminal region enables family members to activate Arp2/3 in response to different upstream signals. |
