| Primary Identifier | IPR035550 | Type | Domain |
| Short Name | Bem1/Scd2_PX |
| description | This entry represents the phox homology (PX) domain found in budding yeast Bem1 and fission yeast Scd2. The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions such as cell signaling, vesicular trafficking, protein sorting, and lipid modification. The PX domain of Bem1 specifically binds phosphatidylinositol-4-phosphate (PI4P) [].Bem1 (Bud emergence protein 1) is involved in establishing cell polarity and morphogenesis []. It interacts with Axl2 (required for axial budding in haploid cells) and forms a complex with Cdc42, Cdc24, and Cla4 [, ]. Scd2 forms complexes with both scd1 and cdc42sp and is required for normal morphology and mating []. |
