| Primary Identifier | IPR037900 | Type | Domain |
| Short Name | CISK_PX |
| description | Cytokine-independent survival kinase (CISK also called SGK3) is a serine/threonine-protein kinase involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration []. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1 []. CISK/SGK3 also regulates many transporters, ion channels, and receptors []. It plays a critical role in hair follicle morphogenesis and hair cycling []. N-terminal to a catalytic kinase domain, CISK contains a PX domain which binds highly phosphorylated PIs, directs membrane localization, and regulates the enzyme's activity [, ].This entry represents the PX domain of CISK. |
