| Primary Identifier | IPR006063 | Type | Family |
| Short Name | HisA_bact_arch |
| description | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (), also known as Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase or HisA, catalyses the fourth step in histidine biosynthesis. HisA from Lactococcus lactis was found to be inactive []. The putative HisA from Thermotoga maritima, is a conspicuous outlier to the set of all other HisA, including experimental HisA from the bacterium Escherichia coli and the Archaeaon Methanococcus voltae. Neighbour joining shows HisA from Thermotoga maritima to be within the HisA family (with HisF as an outgroup) but with a long branch. |
