| Primary Identifier | IPR037504 | Type | Family |
| Short Name | PSI_induc_2 |
| description | Budding yeast Pin2 was identified as a protein that when overexpressed can induce the [PIN+]prion phenotype, which is a prerequisite for prion formation by Sup35, referred to as the [PSI+]prion []. Pin2 localization is dependent on both exo- and endocytosisis. It is an exomer-dependent cargo that localizes at the plasma membrane of the bud early in the cell cycle, and the bud neck at cytokinesis. The prion-like domain (PLD) in Pin2 serves as a Pin2 retention signal in the trans-Golgi network (TGN) and may act as stress-response element. Under environmental stress, Pin2 is endocytosed, and the PLD aggregates and causes sequestration of Pin2. This aggregation is reversible upon stress removal and Pin2 can be re-exported to the plasma membrane []. Why Pin2 needs to be retain under stress is not clear, but it may be related to the observation that Pin2 interacts with various components of the cell-wall integrity pathway. |
