| Primary Identifier | IPR037500 | Type | Family |
| Short Name | Msp1 |
| description | The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation. In plants, Msp1 (also known as AtPRD2) has been identified as one of the SAC components []. Msp1 is required for meiotic spindle organization []and DNA double-strand break formation [].In flowering plants, gametophyte formation relies on meiosis. In meiosis I, the homologous chromosomes are separated into two daughter cells. In meiosis II, the sister chromosomes are then separated into newly formed daughter cells. During prophase I, several events occurs: sister chromatid cohesion, homologous chromosome synapsis, recombination, crossover formation and chromosome segregation. Homologous recombination is initiated from the formation of DNA double-strand breaks (DSBs). The formation of DSBs is catalyzed by Spo11 and its homologues. So far, six Arabidopsis proteins, AtSPO11-1, AtSPO11-2, AtPRD1, AtPRD2, AtPRD3 and AtDFO, have been shown to be involved in DSB formation []. |
