| Primary Identifier | IPR037568 | Type | Family |
| Short Name | Complement_C2 |
| description | This entry represents complement component C2, a component of the classical and lectin activation pathway of complement. C2 is cleaved by C1s (classical) or mannan-binding lectin-associated serine peptidases (lectin) into C2a and C2b []. C2a is a serine endopeptidase from family S1 (chymotrypsin family; MEROPS identifier S01.194) which complexes with C4b to form the C3/C5 convertase []. The complex is stabilized by Mg2+[, ]. The C3/C5 convertase has trypsin-like specificity []. C2 deficiency is the commonest human complement deficiency, which can result in systemic lupus erythematosus-like immune complex diseases []. The C2 gene is part of the major histocompatabaility complex []. |
