| Primary Identifier | IPR037797 | Type | Domain |
| Short Name | FGD2_PH1 |
| description | In general, FGDs (including FGD1, FGD2, FGD3 and FGD4/Frabin) have a RhoGEF (DH) domain, followed by an N-terminal PH domain, a FYVE domain and a C-terminal PH domain. All FGDs are guanine nucleotide exchange factors that activates the Rho GTPase Cdc42, an important regulator of membrane trafficking. The RhoGEF domain is responsible for GEF catalytic activity, while the N-terminal PH domain is involved in intracellular targeting of the DH domain []. FGD2 is expressed by antigen-presenting cells where it may be involved in leukocyte signaling and vesicle trafficking [].This entry represents the N-terminal PH domain of FGD2. |
