| Primary Identifier | IPR035787 | Type | Domain |
| Short Name | SPRY/PRY_TRIM58 |
| description | This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of Trim58, also known as BIA2. TRIM proteins are defined by the presence of the tripartite motif RING/B-box/coiled-coil region, and are also known as RBCC proteins []. Trim58 has been implicated by genome-wide association studies (GWAS) in the regulation of erythrocyte traits, including cell size and number. Trim58 facilitates erythroblast enucleation by inducing proteolytic degradation of the microtubule motor dynein []. |
