| Primary Identifier | IPR021119 | Type | Family |
| Short Name | Poxvirus_F1/C10 |
| description | This entry includes the poxvirus families F1 and C10. C10 proteins are apoptosis regulators, which function to modulate the apoptotic cascades and thereby favour productive viral replication. One of these, M11L inhibits mitochondrial-dependent apoptosis by mimicking and competing with host proteins for the binding and blocking of Bak and Bax, two executioner proteins []. The poxvirus F1 family members are related to Vaccinia virus protein F1L, which interacts with and inhibits NLR-mediated interleukin-1 beta/IL1B production in infected cells. F1L suppresses mitochondrial-dependent apoptosis by binding to the BH3 domain of host BAK and prevents BAK from binding active BAX [, ]. |
