| Primary Identifier | IPR023238 | Type | Family |
| Short Name | FAM175 |
| description | Members of protein family FAM175 include the BRCA1-A complex subunit Abraxas 1 [, ], BRISC complex subunit Abraxas 2 or Abro1 (Abraxas brother protein 1) [, ], and uncharacterised plant proteins.It is thought that BRCA1-A complex subunit Abraxas acts as a central scaffold protein responsible for assembling the various components of the BRCA1-A complex, and mediates recruitment of BRCA1 [, ]. Similarly, Abro1 probably acts as a scaffold facilitating assembly of the various components of BRISC []- the protein does not interact with BRCA1, but binds polyubiquitin []. The primary sequences of these proteins contain an MPN-like domain []. |
