Primary Identifier | IPR037867 | Type | Family |
Short Name | Swd2/WDR82 |
description | This entry includes Swd2 from yeasts and WDR82 from animals. They are part of the Set1/COMPASS complex [].Besides being part of the Set1/COMPASS complex, Swd2 is also a component of the cleavage and polyadenylation factor (CPF) complex and its subcomplex APT [, , ].The COMPASS (Complex Proteins Associated with Set1 or Set1C) is the yeast homologue ofthe human MLL complex, which is required for mono-, di-, and trimethylation of lysine 4 of histone H3 []. It is required in telomeric transcriptional silencing []. The complex consists of Set1, Bre2, Spp1, Sdc1, Shg1, Swd1, Swd2, and Swd3 [, ]. |