| Primary Identifier | IPR023262 | Type | Family |
| Short Name | AROS |
| description | Human SIRT1, an NAD+-dependent deacetylase, plays a role in cell death/ survival, senescence, and endocrine signalling []. Its substrates are well characterised, but evidence for the identity of its direct regulators has been wanting. Recently, the nuclear protein AROS (also termed 40S ribosomal protein S19-binding protein 1 []) has been implicated in the direct regulation of SIRT1 function - this protein has been dubbed 'active regulator of SIRT1. The protein has been shown to enhance SIRT1-mediated deacetylation of p53, in vitro and in vivo, and to inhibit p53-mediated transcriptional activity. It is the first direct SIRT1 regulator to have been identified that modulates p53-mediated growth regulation. |
