| Primary Identifier | IPR035247 | Type | Domain |
| Short Name | PRMT5_TIM |
| description | This entry represents the N-terminal TIM barrel domain of PRMT5.Proteins containing this domain includes Skb1 from S. pombe [], Hsl7 from S. cerevisiae []and their homologues PRMT5 from animals [, , ]and plants []. Skb1 is a mediator of hyperosmotic stress response in Schizosaccharomyces pombe []. Plant PMRT15 is involved in the post-transcriptional regulation of the circadian clock []. Human PRMT5 is a component of multiple protein complexes and contributes to essential cellular processes, such as RNA transport and splicing, cell cycle regulation, tumour growth, and chromatin remodelling, leading to either gene silencing or activation []. |
