| Primary Identifier | IPR013724 | Type | Domain |
| Short Name | GIT_SHD |
| description | This entry represents the Spa2 homology domain (SHD) domain found in the yeast Spa2/Sph1 protein and the mammalian GIT proteins. Budding yeast Spa2 is a component of the polarisome that functions in actin cytoskeletal organisation during polarized growth []. Its paralogue, Sph1, is involved in shmoo formation and bipolar bud site selection []. GIT is a GTPase-activating protein for the ADP ribosylation factor family. It may serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organisation []. Mutations in the Spa2 homology domain (SHD) domain of GIT1 described here interfere with the association of GIT1 with Piccolo, beta-PIX, and focal adhesion kinase []. |
