| Primary Identifier | IPR037714 | Type | Domain |
| Short Name | MSK2_N_dom |
| description | MSK1/2 (Mitogen and Stress-induced Kinase, also known as RSKB) are partially redundant serine/threonine kinases that are phosphorylated downstream of MAPK (Erk and/or p38-mediated) and cAMP signal transduction pathways []. They phosphorylate multiple substrates, including CREB and Histone H3 and regulate specific subsets of Immediate Early genes (IEG) []. They are involved in limiting inflammation in innate immunityand is implicated in neurodegeneration and synaptic plasticity []. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90kDa ribosomal protein S6 kinases (RSKs) []. This entry represents the N-terminal catalytic domain of MSK2. MSK2 is also known as ribosomal protein S6 kinase alpha-4 (RPS6KA4). |
