| Primary Identifier | IPR025717 | Type | Domain |
| Short Name | SAP30_zn-finger |
| description | SAP30 is a subunit of the histone deacetylase complex, and this domain is a zinc-finger. Solution of the structure shows a novel fold comprising two β-strands and two α-helices with the zinc organising centre showing remote resemblance to the treble clef motif. In silico analysis of the structure reveals a highly conserved surface dominated by basic residues. NMR-based analysis of potential ligands for the SAP30 Zn-finger motif indicate a strong preference for nucleic acid substrates. The zinc-finger of SAP30 probably functions as a double-stranded DNA-binding motif, thereby expanding the known functions of both SAP30 and the mammalian Sin3 co-repressor complex []. |
