| Primary Identifier | IPR037755 | Type | Domain |
| Short Name | Plc1_PH |
| description | Saccharomyces cerevisiae Plc1 is a homologue of the delta isoform of mammalian phosphoinositide-specific phospholipase C (PI-PLC) []. It is required for the initial step of inositol polyphosphate (InsP) synthesis. It hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG) []. Plc1 contains an N-terminal PH domain, a EF hand domain, a catalytic domain split into X and Y halves, and a C-terminal C2 domain. This entry represents the PH domain found in Plc1 and its homologues from fungi. |
