| Primary Identifier | IPR037781 | Type | Family |
| Short Name | SKAP_fam |
| description | This entry represents the SKAP (Src kinase-associated phosphoprotein) family, whose members include SKAP1 and SKAP2. They are adaptor proteins that have been implicated in cell adhesion through their association to integrins and cytoplasmic actin []. They contain an N-terminal coiled-coil conformation, a central PH domain and a C-terminal SH3 domain [].SKAP1 (also known as SKAP55) is required for microcluster persistence and movement, junctional stabilization, and integrin-independent adhesion via the T cell receptor (TCR). It interacts with RAPL and RIAM via its N-termianl dimerization (DM) domain. The K152 and D120 within the PH domain of SKAP55 regulate plasma membrane targeting and TCR-mediated activation of LFA-1 (lymphocyte function-associated antigen 1) [].SKAP2 (also known as RA70) is required for beta2 integrin-mediated neutrophil recruitment and functions []. |
