| Primary Identifier | IPR001947 | Type | Family |
| Short Name | Scorpion_toxinS_K_inh |
| description | Scorpion venoms contain a variety of peptides toxic to mammals, insects and crustaceans. Among these peptides there is a family of short toxins (30 to 40 residues) [, ]. This entry represents members of this family with potassium channel blocking activity []. KTX 12 Sp2 toxin from Scorpiops pococki has shown a strong immunosuppressant effect, being an interesting therapeutic agent for autoimmune disease treatment []. This entry also includes NU-buthitoxin-Ptr1a, a toxin that acts as an agonist on melanocortin receptors and does not show activity on mammalian sodium or potassium channels []. Toxin BmK NSPK from Manchurian scorpion, is a voltage-gated potassium (Kv) channel inhibitor that augments neurite extension via NGF/TrkA signaling pathway. As Kv channels may represent molecular targets to modulate spinal cord neurons development and regeneration, they become interesting targets to develop treatments for spinal cord injury []. |
