| Primary Identifier | IPR037955 | Type | Family |
| Short Name | KMT2E |
| description | The protein known as histone-lysine N-methyltransferase 2E (KMT2E, mixed-lineage leukemia 5 or MLL5) has been shown to lack key residues and an essential loop in the the SET-I subdomain required for binding substrate and cofactors []. MLL5 had been thought to be specific for mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2; which are specific tags for epigenetic transcriptional activation), and a component of an MLL5 complex, but the paper describing this alleged complex has been retracted by the authors []. MLL5 mediates hematopoietic cell homeostasis, spermatogenesis, cell cycle progression, and survival [, ]. It is recruited to gene-rich euchromatic regions via the interaction of its plant homeodomain finger with the histone mark H3K4me3 []. Overexpression of the MLL5 gene induced cell cycle arrest in G(1) phase []. |
