| Primary Identifier | IPR037933 | Type | Family |
| Short Name | MAX-like |
| description | Protein max is a transcription regulator that forms a complex with MYC or MAD []. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. MAX is also a component of the E2F6.com-1 []and MLL1 complexes []. Mutations in the MAX gene are associated with hereditary pheochromocytoma, which is a tumour of the chromaffin tissue of the adrenal medulla or sympathetic paraganglia resulting in hypertension [].This entry also includes Mxl-1 and Mxl-3 from Caenorhabditis elegans. Mxl-1 forms complexes with Mdl1. The Mdl-1:Mxl-1 complex functions in both the insulin signaling and dietary restriction pathways and is involved in the control of lifespan in response to dietary restriction []. Mxl-3 is a transcription factor that modulates the inhibition of lipolysis. It also regulates lipid metabolism during nutritional excess []. |
