| Primary Identifier | IPR033010 | Type | Family |
| Short Name | Cdc20/Fizzy |
| description | The anaphase promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that targets mitotic regulators for degradation in exit from mitosis. At the end of mitosis, APC/C is activated by phosphorylation and association with the WD-40 protein Cdc20/Fizzy []. The inhibitory phosphorylation of Cdc20/Fizzy may have a role as a safeguard to keep the cyclosome inactive in early mitosis and under conditions of mitotic checkpoint arrest []. This entry includes Cdc20/Fizzy homologues from fungi, plants and animals.Three characterised budding yeasts homologues are included in this entry: Cdc20, Cdh1 and Ama1. Cdc20 and Cdh1 have been shown to activate APC/C during mitosis, while Ama1 is a meiosis-specific activator of the APC/C []. The APC/C-Cdh1 is also found involved in the cellular response to DNA damage []. Protein cortex from Drosophila melanogasterwhich is a female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) required for the completion of meiosis in oocytes, is also included in this entry. Cortex activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis [, ]. |
