| Primary Identifier | IPR033087 | Type | Family |
| Short Name | Nova-2 |
| description | Nova-2 is a neuron-specific splicing factor that binds to specific pre-mRNA [, ]. It regulates the alternative pre-mRNA splicing in N-type and P-type CaV2 calcium channels [].Nova proteins, including Nova-1 and Nova-2, are implicated in paraneoplastic opsoclonus-myoclonus-ataxia (POMA) syndrome. They were the first mammalian neuron-specific splicing factors identified. Nova-1 is expressed in the subcortical CNS structures in developing and adult mice, while Nova-2 is expressed throughout the CNS and particularly in cortex, olfactory bulb, thalamus, inferior colliculus, etc. They harbour three K-homology (KH) motifs that mediate Nova binding to clusters of YCAY motifs on target pre-mRNAs [, ]. |
