Primary Identifier | IPR033064 | Type | Family |
Short Name | CDCA2 |
description | Cell division cycle-associated protein 2 (CDCA2, also known as Repo-Man) plays an important role in the chromatin organization in post-mitotic nuclei and is essential for proper nuclear envelope reformation and the regulation of DNA damage responses [, ]. Repo-Man is a targeting subunit of the PP1, a phosphatase that is important for cells to progress from mitosis to G1. Repo-Man/PP1 holoenzyme has an increased affinity for the chromatin and can effectively de-phosphorylate histone H3 and possibly other chromosomal substrates []. |