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Protein Domain : Cell division cycle-associated protein 2

Primary Identifier  IPR033064 Type  Family
Short Name  CDCA2
description  Cell division cycle-associated protein 2 (CDCA2, also known as Repo-Man) plays an important role in the chromatin organization in post-mitotic nuclei and is essential for proper nuclear envelope reformation and the regulation of DNA damage responses [, ]. Repo-Man is a targeting subunit of the PP1, a phosphatase that is important for cells to progress from mitosis to G1. Repo-Man/PP1 holoenzyme has an increased affinity for the chromatin and can effectively de-phosphorylate histone H3 and possibly other chromosomal substrates [].

0 Child Features

0 Parent Features

5 Protein Domain Regions