| Primary Identifier | IPR033199 | Type | Family |
| Short Name | DDAH |
| description | Mammalian dimethylarginine dimethylaminohydrolases DDAH1 and DDAH2 have homology with microbial arginine deiminases [], all of them are included in this entry.DDAH hydrolyzes both N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA), two nitric oxide synthase (NOS) inhibitors to yield L-citrulline and the corresponding alkylamine []. This way DDAH relieves the inhibition of NOS and promotes NO biosynthesis. Two isoforms exist, DDAH1 and DDAH2. DDAH1 predominates in tissues that express neuronal NOS []. DDAH2 expression predominates in highly vascularized tissues that express the endothelial NOS isoform and in immune tissues that can express iNOS []. |
