| Primary Identifier | IPR008106 | Type | Family |
| Short Name | Adhesin_MafB |
| description | MafB constitutes a family of secreted toxins in pathogenic Neisseria species, probably involved in interbacterial competition []. Genes immediately downstream of mafB encode a specific immunity protein (MafI). MafB proteins exhibit a signal peptide sequence, a N-terminal conserved domain and a C-terminal variable region. Toxic domains identified at the C terminus include , , , and .The genus Neisseria includes both commensal and pathogenic species. The pathogenic neisseriae are a small group of virulent bacteria that initiate infection at the human host mucosal membranes []. Neisseria gonorrhoeae is passed through sexual transmission and can cause renal failure in extreme cases. The more extreme Neisseria meningitidis is a usually commensal nasopharynx microbe that causes meningococcemia and acute bacterial meningitis, especially in young children and teenagers []. |
